Medicinal Chemistry 3 - Unit 2

Syllabus

Antibiotics

Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes.

• Macrolide: Erythromycin Clarithromycin, Azithromycin.
• Miscellaneous: Chloramphenicol\*, Clindamycin.
• Prodrugs: Basic concepts and application of prodrugs design.
• Antimalarials: Etiology of malaria. Quinolines: SAR, Quinine sulphate, Chloroquine\*, Amodiaquine, Primaquine phosphate, Pamaquine\*, Quinacrine hydrochloride, Mefloquine. Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil.
• Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone.

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