Industrial Pharmacy 1 - Unit 1
Syllabus
Preformulation Studies: Introduction to preformulation, goals and objectives, study of physicochemical characteristics of drug substances.
- Physical properties: Physical form (crystal & amorphous), particle size, shape, flow properties, solubility profile (pKa, pH, partition coefficient), polymorphism
- Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs & its significant
Application of preformulation considerations in the development of solid, liquid oral and parenteral dosage forms and its impact on stability of dosage forms.
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