Medicinal Chemistry 1 - Unit 4
Syllabus
Drugs acting on Central Nervous System
1. Sedatives and Hypnotics
Benzodiazepines:
SAR of Benzodiazepines, Chlordiazepoxide, Diazepam\*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem
Barbiturtes:
SAR of barbiturates, Barbital\*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital
Miscelleneous:
Amides & imides: Glutethmide.
Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol.
Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.
2. B
Phenothiazeines:
SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochloride\*,
Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride,
Prochlorperazine maleate, Trifluoperazine hydrochloride.
Ring Analogues of Phenothiazeines:
Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.
Fluro buterophenones: Haloperidol, Droperidol, Risperidone.
Beta amino ketones: Molindone hydrochloride.
Benzamides: Sulpieride.
3. Anticonvulsants:
SAR of Anticonvulsants, mechanism of anticonvulsant action
Barbiturates: Phenobarbitone, Methabarbital.
Hydantoins: Phenytoin\*, Mephenytoin, Ethotoin
Oxazolidine diones: Trimethadione, Paramethadione
Succinimides: Phensuximide, Methsuximide, Ethosuximide*
Urea and monoacylureas: Phenacemide, Carbamazepine*
Benzodiazepines: Clonazepam
Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate
