Pharmaceutical Organic Chemistry 2
Benzene and its derivatives
- Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
- Reactions of benzene - nitration, sulphonation, halogenationreactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.
- Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction
- Structure and uses of DDT, Saccharin, BHC and Chloramine
Phenol* - Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
Aromatic Amines* - Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts
Aromatic Acids* - Acidity, effect of substituents on acidity and important reactions of benzoic acid.
Fats and Oils
- Fatty acids - reactions.
- Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
- Analytical constants - Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value - significance and principle involved in their determination.
- Synthesis, reactions
- Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives
Stabilities - Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only